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Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: An exploratory study.

journal contribution
posted on 2024-09-22, 23:53 authored by Siroon BekkeringSiroon Bekkering, Christoph SanerChristoph Saner, Boris NovakovicBoris Novakovic, Toby MansellToby Mansell, Danielle LongmoreDanielle Longmore, Zoe McCallum, Anne-Louise Ponsonby, Markus Juonala, Mihai G Netea, Matthew Sabin, Richard SafferyRichard Saffery, Niels P Riksen, David BurgnerDavid Burgner
Cardiometabolic risk accrues across the life course and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but pediatric data are scarce. In a cross-sectional and longitudinal study, we investigated immune cell composition and activation in 31 adolescents with obesity (41.9% male, BMIz>2.5, 14.4 years) and 22 controls with healthy weight (45.1% male, -1.5

Funding

Determinants and cardiometabolic consequences of early life inflammation : National Health and Medical Research Council | 1175744

Epigenetic remodelling of neonatal and maternal monocytes in pregnancy : National Health and Medical Research Council | 1173314

Interfacing epidemiology with systems biology for disease prevention : National Health and Medical Research Council | 1110200

Epigenetics of childhood development and disease : National Health and Medical Research Council | 1045161

History

Pagination

109762-

Volume

27

Publisher

Elsevier

Issue

5

Journal

iScience

Language

eng

Location

United States

Medium

Electronic-eCollection

Number

109762

PII

S2589-0042(24)00984-2

Publisher DOI

Publisher licence

CC BY

Online publication date

2024-04-23

Publication date

2024-05-17

Associated identifiers

grant.7875956 (dimensions-grant-id)

Publication status

  • Published online

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    Keywords

    DiseaseHealth sciencesImmunologyPathophysiologyRisk factor32 Biomedical and Clinical Sciences3210 Nutrition and DieteticsNutritionHeart DiseasePreventionClinical ResearchPediatricCardiovascularChildhood ObesityObesity2.1 Biological and endogenous factorsInflammatory and immune systemOral and gastrointestinal3 Good Health and Well Being

    Licence

    CC BY 4.0

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