Murdoch Childrens Research Institute
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Data from: Impact of Distinct Anti-Androgen Exposures on the Plasma Metabolome in Feminizing Gender-Affirming Hormone Therapy

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posted on 2024-04-29, 00:32 authored by Boris NovakovicBoris Novakovic

Context: The plasma metabolome is a functional readout of metabolic activity and is associated with phenotypes exhibiting sexual dimorphism, such as cardiovascular disease. Sex hormones are thought to play a key role in driving sexual dimorphism. Objective: Gender-affirming hormone therapy (GAHT) is a cornerstone of transgender care, but longitudinal changes in the plasma metabolome with feminizing GAHT have not been described. Methods: Blood samples were collected at baseline and after three and six months of GAHT from transgender women (n=53). Participants were randomized to different anti-androgens, cyproterone acetate or spironolactone. NMR-based metabolomics was used to measure 249 metabolic biomarkers in plasma. Additionally, we used metabolic biomarker data from an unrelated cohort of children and their parents (n=3,748) to identify sex- and age-related metabolite patterns. Data shared: Supplementary Figures and Supplementary Tables containing results related to statistical models are shared here. Additionally, average levels of metabolites per GAHT group over time are presented.


National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R21AI179004

Allen Distinguished Investigator program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation.


MCRI Data Classification

  • Public

Domain Data Controller

Boris Novakovic

Domain Data Steward

Bowon Kim

MCRI Taxonomy

Molecular Immunity

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