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<p><strong>TiNT: Trametinib in Neurofibromatosis type 1 associated tumours</strong></p>
<p>A phase II study of trametinib in paediatric, adolescent and young adult patients with neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas</p>
<p><strong>Statistical Analysis Plan </strong></p>