Murdoch Childrens Research Institute
Browse

Establishing the baseline immune responses to enteric fever-specific antigens in a healthy cohort

Posted on 2025-01-17 - 04:47 authored by MCRI REDCap ServiceAccount
Aim: We have developed the prototype of a new diagnostic assay for detecting enteric fever (typhoid and paratyphoid) with increased sensitivity. We now need to validate that the assay produces i) a low/minimal reading for people without recent infection, but ii) a positive reading for people who are infected. The study will focus on using data from a healthy cohort for optimising the diagnostic assay to meet criterion i).
Methods/participants: Up to 90 participants will be recruited in Melbourne, Australia. A short questionnaire will collect basic, de-identified personal information, including gender, age-group, and recent travel/infection history. Participants are asked to donate one or two (spaced several weeks apart) 15ml of venous blood for use in the diagnostic assay. Outcome from data will be an optimised assay protocol and establishment of the baseline response for a healthy (no recent infection) individual.

CITE THIS COLLECTION

DataCite
No result found
or
Select your citation style and then place your mouse over the citation text to select it.

Project Identifier

112625

Data Steward

dianna.hocking

Data Controller

nancy.wang

HREC Number

112625

Data Retention

Retention period: 5; Destruction plan: where applicable electronic files will be deleted permanently; paper-based records will be disposed of in secure bins.

Storage Location(s)

Long-term storage location(s): HS - MCRI OneDrive, HS - REDCap, S - LabArchives; Network folder:

SHARE

email

Usage metrics

MCRI Data Catalog

AUTHORS (2)

Dianna Hocking

CATEGORIES

need help?