Aim: We have developed the prototype of a new diagnostic assay for detecting enteric fever (typhoid and paratyphoid) with increased sensitivity. We now need to validate that the assay produces i) a low/minimal reading for people without recent infection, but ii) a positive reading for people who are infected. The study will focus on using data from a healthy cohort for optimising the diagnostic assay to meet criterion i). Methods/participants: Up to 90 participants will be recruited in Melbourne, Australia. A short questionnaire will collect basic, de-identified personal information, including gender, age-group, and recent travel/infection history. Participants are asked to donate one or two (spaced several weeks apart) 15ml of venous blood for use in the diagnostic assay. Outcome from data will be an optimised assay protocol and establishment of the baseline response for a healthy (no recent infection) individual.
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Hocking, Dianna; ServiceAccount, MCRI REDCap (2025). Establishing the baseline immune responses to enteric fever-specific antigens in a healthy cohort. Murdoch Childrens Research Institute. Collection. https://doi.org/10.25374/MCRI.c.7630538.v1
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Project Identifier
112625
Data Steward
dianna.hocking
Data Controller
nancy.wang
HREC Number
112625
Data Retention
Retention period: 5; Destruction plan: where applicable electronic files will be deleted permanently; paper-based records will be disposed of in secure bins.